FAST FIVE: Moderna Vaccine Not Effective Against "Mutant" South African COVID Strain, But Works With UK Variant
Moderna Vaccine Not Effective Against “Mutant” South African COVID Strain, But Works With UK Variant Moderna's latest trial data includes some good news…and some bad news.
But it warned that the neutralising antibody response to 501.V2 was sixfold lower than to the original variant, raising concerns that immunity to it may wane significantly, particularly in older people.
Mr Bancel said a few thousand trial participants would be given a booster shot, divided into two groups: one to receive the original vaccine again, and another to get a new vaccine formulated to target 501.V2.
A six-fold reduction in neutralizing titers was observed with the B.1.351 variant relative to prior variants.
Despite this reduction, neutralizing titer levels with B.1.351 remain above levels that are expected to be protective.